MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription

BACKGROUND: Thymidylate synthase (TYMS) is a successful chemotherapeutic target for anticancer therapy. Numerous TYMS inhibitors have been developed and used for treating gastrointestinal cancer now, but they have limited clinical benefits due to the prevalent unresponsiveness and toxicity. It is ur...

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Detalles Bibliográficos
Autores principales: Liu, Tingting, Han, Yumin, Yu, Chunhong, Ji, Yan, Wang, Changxu, Chen, Xiaomin, Wang, Xiang, Shen, Jiayan, Zhang, Yongfeng, Lang, Jing-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838448/
https://www.ncbi.nlm.nih.gov/pubmed/31648989
http://dx.doi.org/10.1016/j.ebiom.2019.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838448/
https://www.ncbi.nlm.nih.gov/pubmed/31648989
http://dx.doi.org/10.1016/j.ebiom.2019.10.003

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