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Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation

Enhancers can regulate the promoters of their target genes over very large genomic distances. It is widely assumed that mechanisms of enhancer action involve the reorganization of three-dimensional chromatin architecture, but this is poorly understood. The predominant model involves physical enhance...

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Detalles Bibliográficos
Autores principales: Benabdallah, Nezha S., Williamson, Iain, Illingworth, Robert S., Kane, Lauren, Boyle, Shelagh, Sengupta, Dipta, Grimes, Graeme R., Therizols, Pierre, Bickmore, Wendy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838673/
https://www.ncbi.nlm.nih.gov/pubmed/31494034
http://dx.doi.org/10.1016/j.molcel.2019.07.038