Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

BACKGROUND: Apelin signalling pathways have important cardiovascular and metabolic functions. Recently, apelin-36-[L28A] and apelin-36-[L28C(30kDa-PEG)], were reported to function independent of the apelin receptor in vivo to produce beneficial metabolic effects without modulating blood pressure. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Nyimanu, Duuamene, Kuc, Rhoda E., Williams, Thomas L., Bednarek, Maria, Ambery, Philip, Jermutus, Lutz, Maguire, Janet J., Davenport, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838674/
https://www.ncbi.nlm.nih.gov/pubmed/31472173
http://dx.doi.org/10.1016/j.peptides.2019.170139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838674/
https://www.ncbi.nlm.nih.gov/pubmed/31472173
http://dx.doi.org/10.1016/j.peptides.2019.170139

Ejemplares similares