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Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

BACKGROUND: Apelin signalling pathways have important cardiovascular and metabolic functions. Recently, apelin-36-[L28A] and apelin-36-[L28C(30kDa-PEG)], were reported to function independent of the apelin receptor in vivo to produce beneficial metabolic effects without modulating blood pressure. We...

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Detalles Bibliográficos
Autores principales:	Nyimanu, Duuamene, Kuc, Rhoda E., Williams, Thomas L., Bednarek, Maria, Ambery, Philip, Jermutus, Lutz, Maguire, Janet J., Davenport, Anthony P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Inc 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838674/ https://www.ncbi.nlm.nih.gov/pubmed/31472173 http://dx.doi.org/10.1016/j.peptides.2019.170139

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