OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis

IL-1β and IL-18 are pro-inflammatory cytokines that are linked to inflammation. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and secretion of IL-1β and IL-18 and, thus, plays a key role in the pathogenesis of many inflammatory conditions, including...

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Detalles Bibliográficos
Autores principales: Sánchez-Fernández, Alba, Skouras, Damaris B., Dinarello, Charles A., López-Vales, Rubèn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839275/
https://www.ncbi.nlm.nih.gov/pubmed/31736980
http://dx.doi.org/10.3389/fimmu.2019.02578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839275/
https://www.ncbi.nlm.nih.gov/pubmed/31736980
http://dx.doi.org/10.3389/fimmu.2019.02578

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