Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects

PF-06751979 is a selective inhibitor of the beta-site amyloid precursor protein cleaving enzyme-1, which is a key aspartyl protease in the generation of amyloid-β (Aβ) peptides, thought to be critical for the cerebral degeneration observed in Alzheimer’s disease. Two Phase I studies (NCT02509117, NC...

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Detalles Bibliográficos
Autores principales: Qiu, Ruolun, Ahn, Jae Eun, Alexander, Robert, Brodney, Michael A., He, Ping, Leurent, Claire, Mancuso, Jessica, Margolin, Richard A., Tankisheva, Ekaterina, Chen, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839502/
https://www.ncbi.nlm.nih.gov/pubmed/31424395
http://dx.doi.org/10.3233/JAD-190228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839502/
https://www.ncbi.nlm.nih.gov/pubmed/31424395
http://dx.doi.org/10.3233/JAD-190228

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