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The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells

The nuclear receptor chicken ovalbumin upstream promoter–transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult Leydig cells, and conditional deletion of the Coup-tfii/Nr2f2 gene impedes their differentiation. Steroid production is also reduced in COUP-TFII–depleted Leydig cells, suppo...

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Detalles Bibliográficos
Autores principales: Mehanovic, Samir, Mendoza-Villarroel, Raifish E, Viger, Robert S, Tremblay, Jacques J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839530/
https://www.ncbi.nlm.nih.gov/pubmed/31723721
http://dx.doi.org/10.1210/js.2019-00266