α,ß-Didehydrosuberoylanilide hydroxamic acid (DDSAHA) as precursor and possible analogue of the anticancer drug SAHA

An alternate synthetic route to the important anticancer drug suberoylanilide hydroxamic acid (SAHA) from its α,ß-didehydro derivative is described. The didehydro derivative is obtained through a cross metathesis reaction between a suitable terminal alkene and N-benzyloxyacrylamide. Some of the dide...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Shital K, Ghosh, Subhankar, Sarkar, Sarita, Bhadra, Kakali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839567/
https://www.ncbi.nlm.nih.gov/pubmed/31728166
http://dx.doi.org/10.3762/bjoc.15.245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839567/
https://www.ncbi.nlm.nih.gov/pubmed/31728166
http://dx.doi.org/10.3762/bjoc.15.245

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