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DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development
OBJECTIVE: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited. DESIGN: We performed genome-wide DNA methyla...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839835/ https://www.ncbi.nlm.nih.gov/pubmed/29141958 http://dx.doi.org/10.1136/gutjnl-2017-314817 |