Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-specific stimulator YC-1 induce a 71° rotatio...

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Detalles Bibliográficos
Autores principales: Horst, Benjamin G, Yokom, Adam L, Rosenberg, Daniel J, Morris, Kyle L, Hammel, Michal, Hurley, James H, Marletta, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839917/
https://www.ncbi.nlm.nih.gov/pubmed/31566566
http://dx.doi.org/10.7554/eLife.50634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839917/
https://www.ncbi.nlm.nih.gov/pubmed/31566566
http://dx.doi.org/10.7554/eLife.50634

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