Cargando…
Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons
The voltage-gated K(+) channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and highly conserved,...
Autores principales: | Vierra, Nicholas C, Kirmiz, Michael, van der List, Deborah, Santana, L Fernando, Trimmer, James S |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839919/ https://www.ncbi.nlm.nih.gov/pubmed/31663850 http://dx.doi.org/10.7554/eLife.49953 |
Ejemplares similares
-
Regulation of neuronal excitation–transcription coupling by Kv2.1-induced clustering of somatic L-type Ca(2+) channels at ER-PM junctions
por: Vierra, Nicholas C., et al.
Publicado: (2021) -
Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function
por: Vierra, Nicholas C., et al.
Publicado: (2022) -
Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels
por: Kirmiz, Michael, et al.
Publicado: (2018) -
Neuronal ER-plasma membrane junctions couple excitation to Ca(2+)-activated PKA signaling
por: Vierra, Nicholas C., et al.
Publicado: (2023) -
Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons
por: Bishop, Hannah I., et al.
Publicado: (2018)