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Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

The magnitude and duration of vertebrate viremia is a critical determinant of arbovirus transmission, geographic spread, and disease severity. We find that multiple alphaviruses, including chikungunya (CHIKV), Ross River (RRV), and o’nyong ‘nyong (ONNV) viruses, are cleared from the circulation of m...

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Detalles Bibliográficos
Autores principales: Carpentier, Kathryn S, Davenport, Bennett J, Haist, Kelsey C, McCarthy, Mary K, May, Nicholas A, Robison, Alexis, Ruckert, Claudia, Ebel, Gregory D, Morrison, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839921/
https://www.ncbi.nlm.nih.gov/pubmed/31596239
http://dx.doi.org/10.7554/eLife.49163