Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling

Proceeding investigations of G protein-coupled receptor (GPCR) heterocomplexes have demonstrated that the dopamine D2 receptor (D(2)R), one of the hub receptors in the physiology of schizophrenia, interacts with both the neurotensin NTS1 (NTS1R) and the serotonin 5-HT(2A) receptor (5-HT(2A)R) in cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Plach, Michael, Schäfer, Thorsten, Borroto-Escuela, Dasiel Oscar, Weikert, Dorothée, Gmeiner, Peter, Fuxe, Kjell, Friedland, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841725/
https://www.ncbi.nlm.nih.gov/pubmed/31704949
http://dx.doi.org/10.1038/s41598-019-52540-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841725/
https://www.ncbi.nlm.nih.gov/pubmed/31704949
http://dx.doi.org/10.1038/s41598-019-52540-8

Ejemplares similares