Improved polygenic prediction by Bayesian multiple regression on summary statistics

Accurate prediction of an individual’s phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from genome-wide association studie...

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Detalles Bibliográficos
Autores principales: Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian, Visscher, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841727/
https://www.ncbi.nlm.nih.gov/pubmed/31704910
http://dx.doi.org/10.1038/s41467-019-12653-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841727/
https://www.ncbi.nlm.nih.gov/pubmed/31704910
http://dx.doi.org/10.1038/s41467-019-12653-0

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