Cell proliferation and invasion are regulated differently by EGFR and MRP1 in T-DM1-resistant breast cancer cells

We recently reported that T-DM1-resistant JIMT1 (T-DM1R-JIMT1) cells exhibited high invasive activity via EGFR and integrin cooperated pathways and gained cross-resistance to doxorubicin. Here, we show that EGFR positively coordinates with MRP1 in T-DM1R-JIMT1 cells to contribute to cross-resistance...

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Detalles Bibliográficos
Autores principales: Endo, Yukinori, Lyon, Sarah, Shen, Yi, Mohan, Nishant, Wu, Wen Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842003/
https://www.ncbi.nlm.nih.gov/pubmed/31704984
http://dx.doi.org/10.1038/s41598-019-52797-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842003/
https://www.ncbi.nlm.nih.gov/pubmed/31704984
http://dx.doi.org/10.1038/s41598-019-52797-z

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