Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)

BACKGROUND: DNA transposon-based vectors are effective nonviral tools for gene therapy and genetic engineering of cells. However, promoter DNA methylation and a near-random integration profile, which can result in transgene integration into heterochromatin, renders such vectors vulnerable to transcr...

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Detalles Bibliográficos
Autores principales: Skipper, Kristian Alsbjerg, Hollensen, Anne Kruse, Antoniou, Michael N., Mikkelsen, Jacob Giehm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842454/
https://www.ncbi.nlm.nih.gov/pubmed/31706316
http://dx.doi.org/10.1186/s12896-019-0570-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842454/
https://www.ncbi.nlm.nih.gov/pubmed/31706316
http://dx.doi.org/10.1186/s12896-019-0570-2

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