MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells

BACKGROUND: Both cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane pH, the Na(+)/H(+) exchanger NHE1 plays a significant part in human melanoma (MV3) cell migration and invasion. Because NHE1, besides its pH-regulato...

Descripción completa

Detalles Bibliográficos
Autores principales: Keurhorst, Dennis, Liashkovich, Ivan, Frontzek, Fabian, Nitzlaff, Svenja, Hofschröer, Verena, Dreier, Rita, Stock, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842528/
https://www.ncbi.nlm.nih.gov/pubmed/31728131
http://dx.doi.org/10.1186/s12935-019-1015-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842528/
https://www.ncbi.nlm.nih.gov/pubmed/31728131
http://dx.doi.org/10.1186/s12935-019-1015-7

Ejemplares similares