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MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells

BACKGROUND: Both cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane pH, the Na(+)/H(+) exchanger NHE1 plays a significant part in human melanoma (MV3) cell migration and invasion. Because NHE1, besides its pH-regulato...

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Detalles Bibliográficos
Autores principales:	Keurhorst, Dennis, Liashkovich, Ivan, Frontzek, Fabian, Nitzlaff, Svenja, Hofschröer, Verena, Dreier, Rita, Stock, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842528/ https://www.ncbi.nlm.nih.gov/pubmed/31728131 http://dx.doi.org/10.1186/s12935-019-1015-7

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