Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

In order to produce effective antibodies, B cells undergo rapid somatic hypermutation (SHM) and selection for binding affinity to antigen via a process called affinity maturation. The similarities between this process and evolution by natural selection have led many groups to use phylogenetic method...

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Detalles Bibliográficos
Autores principales: Hoehn, Kenneth B., Vander Heiden, Jason A., Zhou, Julian Q., Lunter, Gerton, Pybus, Oliver G., Kleinstein, Steven H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842591/
https://www.ncbi.nlm.nih.gov/pubmed/31636219
http://dx.doi.org/10.1073/pnas.1906020116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842591/
https://www.ncbi.nlm.nih.gov/pubmed/31636219
http://dx.doi.org/10.1073/pnas.1906020116

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