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Deletions associated with stabilization of the Top1 cleavage complex in yeast are products of the nonhomologous end-joining pathway
Topoisomerase I (Top1) resolves supercoils by nicking one DNA strand and facilitating religation after torsional stress has been relieved. During its reaction cycle, Top1 forms a covalent cleavage complex (Top1cc) with the nicked DNA, and this intermediate can be converted into a toxic double-strand...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842612/ https://www.ncbi.nlm.nih.gov/pubmed/31636207 http://dx.doi.org/10.1073/pnas.1914081116 |