Remifentanil-Induced Secondary Hyperalgesia Is Not Prevented By Preoperative Acetazolamide Administration In Patients Undergoing Total Thyroidectomy: A Randomized Controlled Trial

PURPOSE: Acute administration of remifentanil may lead to opioid-induced hyperalgesia (OIH). Studies in mice suggest that OIH is mediated by impaired anionic homeostasis in spinal lamina I neurons due to a down-regulation of the K(+)-Cl(−) co-transporter KCC2, which was reverted using acetazolamide...

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Detalles Bibliográficos
Autores principales: Gutiérrez, Rodrigo, Contreras, Felipe, Blanch, Alonso, Bravo, Daniela, Egaña, José I, Rappoport, Daniel, Cabané, Patricio, Rodríguez, Francisco, Penna, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842739/
https://www.ncbi.nlm.nih.gov/pubmed/31807056
http://dx.doi.org/10.2147/JPR.S221131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842739/
https://www.ncbi.nlm.nih.gov/pubmed/31807056
http://dx.doi.org/10.2147/JPR.S221131

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