Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation

α-Synuclein (α-Syn) forms pathological amyloid aggregates deposited in Lewy bodies and Lewy neurites in the brain of Parkinson’s disease (PD) patients. Heat shock proteins (Hsps) are the major components of the cellular chaperone network, which are responsible for preventing proteins from amyloid ag...

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Detalles Bibliográficos
Autores principales: Jia, Chunyu, Ma, Xiaojuan, Liu, Zhenying, Gu, Jinge, Zhang, Xiang, Li, Dan, Zhang, Shengnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842937/
https://www.ncbi.nlm.nih.gov/pubmed/31749672
http://dx.doi.org/10.3389/fnins.2019.01124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842937/
https://www.ncbi.nlm.nih.gov/pubmed/31749672
http://dx.doi.org/10.3389/fnins.2019.01124

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