Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs. Multivalent lectin-mediated interactions of SP-D with IAVs result in viral aggregation, reduced epithelial infect...

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Detalles Bibliográficos
Autores principales: van Eijk, Martin, Hillaire, Marine L. B., Rimmelzwaan, Guus F., Rynkiewicz, Michael J., White, Mitchell R., Hartshorn, Kevan L., Hessing, Martin, Koolmees, Peter A., Tersteeg, Monique H., van Es, Maarten H., Meijerhof, Tjarko, Huckriede, Anke, Haagsman, Henk P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842947/
https://www.ncbi.nlm.nih.gov/pubmed/31749796
http://dx.doi.org/10.3389/fimmu.2019.02476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842947/
https://www.ncbi.nlm.nih.gov/pubmed/31749796
http://dx.doi.org/10.3389/fimmu.2019.02476

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