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Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India

The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high...

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Autores principales: Balamurugan, Ramadass, Pugazhendhi, Srinivasan, Balachander, Gowri M., Dharmalingam, Tamilselvan, Mortimer, Elissa K, Gopalsamy, Geetha L., Woodman, Richard J., Meng, Rosie, Alpers, David H., Manary, Mark, Binder, Henry J., Brown, Ian L., Young, Graeme P., Ramakrishna, Balakrishnan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843365/
https://www.ncbi.nlm.nih.gov/pubmed/31618992
http://dx.doi.org/10.3390/ijerph16203922
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author Balamurugan, Ramadass
Pugazhendhi, Srinivasan
Balachander, Gowri M.
Dharmalingam, Tamilselvan
Mortimer, Elissa K
Gopalsamy, Geetha L.
Woodman, Richard J.
Meng, Rosie
Alpers, David H.
Manary, Mark
Binder, Henry J.
Brown, Ian L.
Young, Graeme P.
Ramakrishna, Balakrishnan S.
author_facet Balamurugan, Ramadass
Pugazhendhi, Srinivasan
Balachander, Gowri M.
Dharmalingam, Tamilselvan
Mortimer, Elissa K
Gopalsamy, Geetha L.
Woodman, Richard J.
Meng, Rosie
Alpers, David H.
Manary, Mark
Binder, Henry J.
Brown, Ian L.
Young, Graeme P.
Ramakrishna, Balakrishnan S.
author_sort Balamurugan, Ramadass
collection PubMed
description The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. At entry, stunted children had lower SCFA concentrations compared to healthy children. Both types of RS led to a significant decrease in fecal pH and increase in fecal acetate and propionate in both healthy and stunted children. However, while HAMS increased fecal butyrate in both groups of children, HAMSA increased butyrate in healthy but not stunted children. Furthermore, healthy children showed a significantly greater increase than stunted children in both acetate and butyrate when fed either RS. No adverse effects were reported with either RS. Stunted children have impaired capacity to ferment certain types of RS which has implications for choice of RS in formulations aimed at improving microbial function in stunted children.
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spelling pubmed-68433652019-11-25 Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India Balamurugan, Ramadass Pugazhendhi, Srinivasan Balachander, Gowri M. Dharmalingam, Tamilselvan Mortimer, Elissa K Gopalsamy, Geetha L. Woodman, Richard J. Meng, Rosie Alpers, David H. Manary, Mark Binder, Henry J. Brown, Ian L. Young, Graeme P. Ramakrishna, Balakrishnan S. Int J Environ Res Public Health Article The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. At entry, stunted children had lower SCFA concentrations compared to healthy children. Both types of RS led to a significant decrease in fecal pH and increase in fecal acetate and propionate in both healthy and stunted children. However, while HAMS increased fecal butyrate in both groups of children, HAMSA increased butyrate in healthy but not stunted children. Furthermore, healthy children showed a significantly greater increase than stunted children in both acetate and butyrate when fed either RS. No adverse effects were reported with either RS. Stunted children have impaired capacity to ferment certain types of RS which has implications for choice of RS in formulations aimed at improving microbial function in stunted children. MDPI 2019-10-15 2019-10 /pmc/articles/PMC6843365/ /pubmed/31618992 http://dx.doi.org/10.3390/ijerph16203922 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balamurugan, Ramadass
Pugazhendhi, Srinivasan
Balachander, Gowri M.
Dharmalingam, Tamilselvan
Mortimer, Elissa K
Gopalsamy, Geetha L.
Woodman, Richard J.
Meng, Rosie
Alpers, David H.
Manary, Mark
Binder, Henry J.
Brown, Ian L.
Young, Graeme P.
Ramakrishna, Balakrishnan S.
Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
title Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
title_full Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
title_fullStr Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
title_full_unstemmed Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
title_short Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
title_sort effect of native and acetylated dietary resistant starches on intestinal fermentative capacity of normal and stunted children in southern india
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843365/
https://www.ncbi.nlm.nih.gov/pubmed/31618992
http://dx.doi.org/10.3390/ijerph16203922
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