Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations

The spliceosome accurately promotes precursor messenger-RNA splicing by recognizing specific noncoding intronic tracts including the branch point sequence (BPS) and the 3’-splice-site (3’SS). Mutations of Hsh155 (yeast)/SF3B1 (human), which is a protein of the SF3b factor involved in BPS recognition...

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Detalles Bibliográficos
Autores principales: Borišek, Jure, Saltalamacchia, Andrea, Gallì, Anna, Palermo, Giulia, Molteni, Elisabetta, Malcovati, Luca, Magistrato, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843770/
https://www.ncbi.nlm.nih.gov/pubmed/31640290
http://dx.doi.org/10.3390/biom9100633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843770/
https://www.ncbi.nlm.nih.gov/pubmed/31640290
http://dx.doi.org/10.3390/biom9100633

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