Impact of mouse contamination in genomic profiling of patient-derived models and best practice for robust analysis

BACKGROUND: Patient-derived xenograft and cell line models are popular models for clinical cancer research. However, the inevitable inclusion of a mouse genome in a patient-derived model is a remaining concern in the analysis. Although multiple tools and filtering strategies have been developed to a...

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Detalles Bibliográficos
Autores principales: Jo, Se-Young, Kim, Eunyoung, Kim, Sangwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844030/
https://www.ncbi.nlm.nih.gov/pubmed/31707992
http://dx.doi.org/10.1186/s13059-019-1849-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844030/
https://www.ncbi.nlm.nih.gov/pubmed/31707992
http://dx.doi.org/10.1186/s13059-019-1849-2

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