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Impact of mouse contamination in genomic profiling of patient-derived models and best practice for robust analysis
BACKGROUND: Patient-derived xenograft and cell line models are popular models for clinical cancer research. However, the inevitable inclusion of a mouse genome in a patient-derived model is a remaining concern in the analysis. Although multiple tools and filtering strategies have been developed to a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844030/ https://www.ncbi.nlm.nih.gov/pubmed/31707992 http://dx.doi.org/10.1186/s13059-019-1849-2 |