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Directed C(sp(3))–H arylation of tryptophan: transformation of the directing group into an activated amide

The 8-aminoquinoline (8AQ) directed C(sp(3))–H functionalization was applied in the synthesis of β-arylated tryptophan derivatives. The laborious protecting group reorganization towards α-amino acids compatible for solid phase peptide synthesis (SPPS) was cut short by the transformation of the direc...

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Detalles Bibliográficos
Autores principales: Nicke, Lennart, Horx, Philip, Harms, Klaus, Geyer, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844298/
https://www.ncbi.nlm.nih.gov/pubmed/31803437
http://dx.doi.org/10.1039/c9sc03440d