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Directed C(sp(3))–H arylation of tryptophan: transformation of the directing group into an activated amide

The 8-aminoquinoline (8AQ) directed C(sp(3))–H functionalization was applied in the synthesis of β-arylated tryptophan derivatives. The laborious protecting group reorganization towards α-amino acids compatible for solid phase peptide synthesis (SPPS) was cut short by the transformation of the direc...

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Detalles Bibliográficos
Autores principales: Nicke, Lennart, Horx, Philip, Harms, Klaus, Geyer, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844298/
https://www.ncbi.nlm.nih.gov/pubmed/31803437
http://dx.doi.org/10.1039/c9sc03440d
Descripción
Sumario:The 8-aminoquinoline (8AQ) directed C(sp(3))–H functionalization was applied in the synthesis of β-arylated tryptophan derivatives. The laborious protecting group reorganization towards α-amino acids compatible for solid phase peptide synthesis (SPPS) was cut short by the transformation of the directing group into an activated amide, which was either used directly in peptide coupling or in the gram scale synthesis of storable Fmoc-protected amino acids for SPPS. In this work, directed C–H activation and nonplanar amide chemistry complement each other for the synthesis of hybrids between phenylalanine and tryptophan with restricted side chain mobility.