Cargando…

Expression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects

CD137-targeting immune therapy, which activates anti-tumor T effector cell responses, seems to be an attractive concept in clinical oncology. Recent evidence has demonstrated that tumor cells besides T cells and antigen-presenting cells are able to express CD137 and CD137L. Here we aimed to identify...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grimmig, Tanja, Gasser, Martin, Moench, Romana, Zhu, Lang-Jing, Nawalaniec, Karol, Callies, Simone, Wagner, Martin, Polat, Buelent, Mothi, Suraj Sarvode, Luo, Yueming, Ribas, Carmen M., Malafaia, Osvaldo, Hsiao, Li-Li, Waaga-Gasser, Ana Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844327/ https://www.ncbi.nlm.nih.gov/pubmed/31741755 http://dx.doi.org/10.1080/2162402X.2019.1651622

Ejemplares similares

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer
por: Moench, Romana, et al.
Publicado: (2022)

Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis
por: Grimmig, Tanja, et al.
Publicado: (2017)

PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner
por: Cao, Minghua, et al.
Publicado: (2022)

KMP01D Demonstrates Beneficial Anti-inflammatory Effects on Immune Cells: An ex vivo Preclinical Study of Patients With Colorectal Cancer
por: Gasser, Martin, et al.
Publicado: (2020)

Toll Like Receptor 2, 4, and 9 Signaling Promotes Autoregulative Tumor Cell Growth and VEGF/PDGF Expression in Human Pancreatic Cancer
por: Grimmig, Tanja, et al.
Publicado: (2016)

Clinical Significance of Disseminated Pluripotent Tumor Cell Signature Expression in the Bone Marrow from Patients with Colorectal Cancer
por: Gasser, Martin, et al.
Publicado: (2017)

Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer
por: Moench, Romana, et al.
Publicado: (2016)

The role of FOXP3 in disease progression in colorectal cancer patients
por: Grimmig, Tanja, et al.
Publicado: (2013)

TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer
por: GRIMMIG, TANJA, et al.
Publicado: (2015)

Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
por: Kim, Mia, et al.
Publicado: (2013)

IS THERE A CLINICAL PATHOLOGICAL CORRELATION OF COLORECTAL ADENOCARCINOMA WITH THE IMMUNOHISTOCHEMICAL EXPRESSION OF OPN AND ABCB5?
por: CASTOLDI, Diogo Francesco, et al.
Publicado: (2021)

A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome
por: Djuzenova, Cholpon S., et al.
Publicado: (2015)

CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species
por: Yeo, Yee Andy, et al.
Publicado: (2012)

The Kidney Failure Risk Equation Score and CKD Care Delivery Measures: A Cross-sectional Study
por: Ahmed, Salman, et al.
Publicado: (2021)

Physician Attitudes on Kidney Biopsies for Research: A Survey Study
por: McMahon, Gearoid M., et al.
Publicado: (2019)

CD137-CD137 Ligand Interactions in Inflammation
por: Kwon, Byungsuk
Publicado: (2009)

High Prevalence and Low Awareness of Albuminuria in the Community Setting in the KDSAP
por: Zhuo, Min, et al.
Publicado: (2019)

Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases
por: Grimm, Martin, et al.
Publicado: (2010)

The intraportal injection model: A practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer
por: Thalheimer, Andreas, et al.
Publicado: (2009)

Paediatric HIV - trends & challenges
por: Mothi, S.N., et al.
Publicado: (2011)

CIP2A Influences Survival in Colon Cancer and Is Critical for Maintaining Myc Expression
por: Wiegering, Armin, et al.
Publicado: (2013)

Modulation of Calcium Homeostasis May Be Associated with Susceptibility to Renal Cell Carcinoma in Diabetic Nephropathy Rats
por: Luo, Yueming, et al.
Publicado: (2020)

Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
por: Kwon, Byungsuk
Publicado: (2015)

ARE STEM CELL MARKER EXPRESSION AND CD133 ANALYSIS RELEVANT TO DIFFERENTIATE COLORECTAL CANCER?
por: CZECZKO, Leticia Elizabeth Augustin, et al.
Publicado: (2021)

ARE STEM CELL MARKER EXPRESSION AND CD133 ANALYSIS RELEVANT TO DIFFERENTIATE COLORECTAL CANCER?
por: CZECZKO, Leticia Elizabeth Augustin, et al.
Publicado: (2021)

Mimicking Metastases Including Tumor Stroma: A New Technique to Generate a Three-Dimensional Colorectal Cancer Model Based on a Biological Decellularized Intestinal Scaffold
por: Nietzer, Sarah, et al.
Publicado: (2016)

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
por: Luu, Khang, et al.
Publicado: (2021)

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity
por: Choi, Beom K., et al.
Publicado: (2020)

CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study
por: Tsaur, Igor, et al.
Publicado: (2015)

Tumor Necrosis Factor-α is Associated with Positive Lymph Node Status in Patients with Recurrence of Colorectal Cancer – Indications for Anti-TNF-α Agents in Cancer Treatment
por: Grimm, M., et al.
Publicado: (2010)

Adenosinergic Pathway and Linked Suppression: Two Critical Suppressive Mechanisms of Human Donor Antigen Specific Regulatory T Cell Lines Expanded Post Transplant
por: Tripathi, Sudipta, et al.
Publicado: (2022)

The Beneficial Role of Auricular Point Pressure in Insomnia and Anxiety in Isolated COVID-19 Patients
por: Luo, Yueming, et al.
Publicado: (2021)

NKG2D ligands link oncogenic RAS to innate immunity
por: Ho, Samantha S.W., et al.
Publicado: (2013)

Species Difference of CD137 Ligand Signaling in Human and Murine Monocytes
por: Tang, Qianqiao, et al.
Publicado: (2011)

Regulation of Inflammation by Bidirectional Signaling through CD137 and Its Ligand
por: Kwon, Byungsuk
Publicado: (2012)

Electronic protocol for clinical data collection in chronic visceral ischemia
por: Brandão, Adriana Buechner de Freitas, et al.
Publicado: (2017)

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
por: Wong, Hiu Yi, et al.
Publicado: (2020)

Empirically defining treatment response and remission in body dysmorphic disorder
por: Fernández de la Cruz, Lorena, et al.
Publicado: (2021)

Resistance to the mTOR-inhibitor RAD001 elevates integrin α2- and β1-triggered motility, migration and invasion of prostate cancer cells
por: Tsaur, I, et al.
Publicado: (2012)

Ureaplasma Species Differentially Modulate Pro- and Anti-Inflammatory Cytokine Responses in Newborn and Adult Human Monocytes Pushing the State Toward Pro-Inflammation
por: Glaser, Kirsten, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j6a7ru6vhjqn4dc2b28afsp45t