Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors

Activation of Toll-like receptor 9 (TLR9) is known to foster innate and adaptive immune responses and thus improve immune-mediated control of malignant disease. Lefitolimod is a potent TLR9 agonist without chemical modification developed for immunotherapeutic strategies. Modulation of the tumor micr...

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Detalles Bibliográficos
Autores principales: Kapp, Kerstin, Volz, Barbara, Oswald, Detlef, Wittig, Burghardt, Baumann, Matthias, Schmidt, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844329/
https://www.ncbi.nlm.nih.gov/pubmed/31741757
http://dx.doi.org/10.1080/2162402X.2019.1659096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844329/
https://www.ncbi.nlm.nih.gov/pubmed/31741757
http://dx.doi.org/10.1080/2162402X.2019.1659096

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