Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE. Among them, compound 4c was identified as the most p...

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Detalles Bibliográficos
Autores principales: Fu, Jie, Bao, Fengqi, Gu, Min, Liu, Jing, Zhang, Zhipeng, Ding, Jiaoli, Xie, Sai-Sai, Ding, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844382/
https://www.ncbi.nlm.nih.gov/pubmed/31694418
http://dx.doi.org/10.1080/14756366.2019.1687460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844382/
https://www.ncbi.nlm.nih.gov/pubmed/31694418
http://dx.doi.org/10.1080/14756366.2019.1687460

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