Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening. All the newly synthesised compounds were evaluated in vitro for...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Wen, Yu, Gao, Lina, Gao, Liang, He, Fengjun, Zhou, Jingxian, Wang, Junwei, Dai, Rupeng, Chen, Xiaojing, Kang, Di, Hu, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844396/
https://www.ncbi.nlm.nih.gov/pubmed/31682465
http://dx.doi.org/10.1080/14756366.2019.1673745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844396/
https://www.ncbi.nlm.nih.gov/pubmed/31682465
http://dx.doi.org/10.1080/14756366.2019.1673745

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