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How to design a dose-finding study on combined agents: Choice of design and development of R functions
BACKGROUND: In oncology, the aim of dose-finding phase I studies is to find the maximum tolerated dose for further studies. The use of combinations of two or more agents is increasing. Several dose-finding designs have been proposed for this situation. Numerous publications have however pointed out...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844553/ https://www.ncbi.nlm.nih.gov/pubmed/31710632 http://dx.doi.org/10.1371/journal.pone.0224940 |