Dynamics of the DEAD-box ATPase Prp5 RecA-like domains provide a conformational switch during spliceosome assembly

The DEAD-box family of proteins are ATP-dependent, RNA-binding proteins implicated in many aspects of RNA metabolism. Pre-mRNA splicing in eukaryotes requires three DEAD-box ATPases (Prp5, Prp28 and Sub2), the molecular mechanisms of which are poorly understood. Here, we use single molecule FRET (sm...

Descripción completa

Detalles Bibliográficos
Autores principales: Beier, David H, Carrocci, Tucker J, van der Feltz, Clarisse, Tretbar, U Sandy, Paulson, Joshua C, Grabowski, Nikolai, Hoskins, Aaron A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846040/
https://www.ncbi.nlm.nih.gov/pubmed/31712821
http://dx.doi.org/10.1093/nar/gkz765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846040/
https://www.ncbi.nlm.nih.gov/pubmed/31712821
http://dx.doi.org/10.1093/nar/gkz765

Ejemplares similares