Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1

The rapid RNase H1-dependent mislocalization of heterodimer proteins P54nrb and PSF to nucleoli is an early event in the pathway that explains the effects of most toxic phosphorothioate ASOs (PS-ASOs). Using a recently developed NanoLuciferace (NLuc)-based structural complementation reporter system...

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Detalles Bibliográficos
Autores principales: Vickers, Timothy A, Rahdar, Meghdad, Prakash, Thazha P, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846478/
https://www.ncbi.nlm.nih.gov/pubmed/31495875
http://dx.doi.org/10.1093/nar/gkz771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846478/
https://www.ncbi.nlm.nih.gov/pubmed/31495875
http://dx.doi.org/10.1093/nar/gkz771

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