Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition

The complex between Trm7 and Trm734 (Trm7–Trm734) from Saccharomyces cerevisiae catalyzes 2′-O-methylation at position 34 in tRNA. We report biochemical and structural studies of the Trm7–Trm734 complex. Purified recombinant Trm7–Trm734 preferentially methylates tRNA(Phe) transcript variants possess...

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Detalles Bibliográficos
Autores principales: Hirata, Akira, Okada, Keisuke, Yoshii, Kazuaki, Shiraishi, Hiroyuki, Saijo, Shinya, Yonezawa, Kento, Shimizu, Nobutaka, Hori, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847430/
https://www.ncbi.nlm.nih.gov/pubmed/31586407
http://dx.doi.org/10.1093/nar/gkz856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847430/
https://www.ncbi.nlm.nih.gov/pubmed/31586407
http://dx.doi.org/10.1093/nar/gkz856

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