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Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition

The complex between Trm7 and Trm734 (Trm7–Trm734) from Saccharomyces cerevisiae catalyzes 2′-O-methylation at position 34 in tRNA. We report biochemical and structural studies of the Trm7–Trm734 complex. Purified recombinant Trm7–Trm734 preferentially methylates tRNA(Phe) transcript variants possess...

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Detalles Bibliográficos
Autores principales:	Hirata, Akira, Okada, Keisuke, Yoshii, Kazuaki, Shiraishi, Hiroyuki, Saijo, Shinya, Yonezawa, Kento, Shimizu, Nobutaka, Hori, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847430/ https://www.ncbi.nlm.nih.gov/pubmed/31586407 http://dx.doi.org/10.1093/nar/gkz856

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