Improving The Oral Absorption Of Nintedanib By A Self-Microemulsion Drug Delivery System: Preparation And In Vitro/In Vivo Evaluation

OBJECTIVE: Nintedanib (NDNB) is a triple receptor tyrosine kinase inhibitor with poor solubility in neutral conditions and low bioavailability. A self-microemulsifying drug delivery system (SMEDDS) of NDNB was developed to improve drug solubility in physical conditions and absorption in vivo. METHOD...

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Detalles Bibliográficos
Autores principales: Liu, Hongfei, Mei, Jiaao, Xu, Ying, Tang, Lei, Chen, Daquan, Zhu, Yating, Huang, Shuguang, Webster, Thomas J, Ding, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847991/
https://www.ncbi.nlm.nih.gov/pubmed/31806968
http://dx.doi.org/10.2147/IJN.S224044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847991/
https://www.ncbi.nlm.nih.gov/pubmed/31806968
http://dx.doi.org/10.2147/IJN.S224044

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