Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells

Clinical use of olanzapine frequently causes severe hyperglycemia as an adverse effect. In this study, we elucidated mechanisms by which olanzapine reduced insulin secretion using the hamster pancreatic β-cell line HIT-T15. Reverse transcriptional-PCR analysis revealed expression of dopamine (D(2),...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagata, Mao, Yokooji, Tomoharu, Nakai, Tomoe, Miura, Yumika, Tomita, Takashi, Taogoshi, Takanori, Sugimoto, Yumi, Matsuo, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848069/
https://www.ncbi.nlm.nih.gov/pubmed/31712714
http://dx.doi.org/10.1038/s41598-019-52590-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848069/
https://www.ncbi.nlm.nih.gov/pubmed/31712714
http://dx.doi.org/10.1038/s41598-019-52590-y

Ejemplares similares