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Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells

Clinical use of olanzapine frequently causes severe hyperglycemia as an adverse effect. In this study, we elucidated mechanisms by which olanzapine reduced insulin secretion using the hamster pancreatic β-cell line HIT-T15. Reverse transcriptional-PCR analysis revealed expression of dopamine (D(2),...

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Detalles Bibliográficos
Autores principales:	Nagata, Mao, Yokooji, Tomoharu, Nakai, Tomoe, Miura, Yumika, Tomita, Takashi, Taogoshi, Takanori, Sugimoto, Yumi, Matsuo, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848069/ https://www.ncbi.nlm.nih.gov/pubmed/31712714 http://dx.doi.org/10.1038/s41598-019-52590-y

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