A feedback loop of conditionally stable circuits drives the cell cycle from checkpoint to checkpoint

We perform logic-based network analysis on a model of the mammalian cell cycle. This model is composed of a Restriction Switch driving cell cycle commitment and a Phase Switch driving mitotic entry and exit. By generalizing the concept of stable motif, i.e., a self-sustaining positive feedback loop...

Descripción completa

Detalles Bibliográficos
Autores principales: Deritei, Dávid, Rozum, Jordan, Ravasz Regan, Erzsébet, Albert, Réka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848090/
https://www.ncbi.nlm.nih.gov/pubmed/31712566
http://dx.doi.org/10.1038/s41598-019-52725-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848090/
https://www.ncbi.nlm.nih.gov/pubmed/31712566
http://dx.doi.org/10.1038/s41598-019-52725-1

Ejemplares similares