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A feedback loop of conditionally stable circuits drives the cell cycle from checkpoint to checkpoint
We perform logic-based network analysis on a model of the mammalian cell cycle. This model is composed of a Restriction Switch driving cell cycle commitment and a Phase Switch driving mitotic entry and exit. By generalizing the concept of stable motif, i.e., a self-sustaining positive feedback loop...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848090/ https://www.ncbi.nlm.nih.gov/pubmed/31712566 http://dx.doi.org/10.1038/s41598-019-52725-1 |