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FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming

FOXH1 is a primitive-streak specifier and ACTIVIN co-effector that plays an important role in development, and positively regulates the generation of human induced pluripotent stem cells (iPSCs) from somatic cells by OCT4, SOX2, KLF4, and MYC (OSKM) transduction. However, the mechanism and upstream...

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Detalles Bibliográficos
Autores principales: Wang, Ling, Su, Yue, Huang, Chang, Yin, Yexuan, Zhu, Jiaqi, Knupp, Alec, Chu, Alexander, Tang, Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848184/
https://www.ncbi.nlm.nih.gov/pubmed/31712708
http://dx.doi.org/10.1038/s41598-019-52861-8