ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown. We generated ATM knockdowns (KD) and CRISPR knock outs (KO) in glioblastoma (LN18, LN229) and ovarian c...

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Detalles Bibliográficos
Autores principales: Ali, Reem, Alabdullah, Muslim, Miligy, Islam, Normatova, Makhliyo, Babaei-Jadidi, Roya, S. Nateri, Abdolrahman, Rakha, Emad A., Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848936/
https://www.ncbi.nlm.nih.gov/pubmed/31635307
http://dx.doi.org/10.3390/cells8101271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848936/
https://www.ncbi.nlm.nih.gov/pubmed/31635307
http://dx.doi.org/10.3390/cells8101271

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