Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR

BACKGROUND: Patients with metastatic colorectal cancer can benefit from anti-EGFR therapy, such as cetuximab and panitumumab. However, colorectal cancers harboring constitutive activating mutations in KRAS, NRAS and BRAF genes are not responsive to anti-EGFR therapy. To select patients for appropria...

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Detalles Bibliográficos
Autores principales: Nagakubo, Yuki, Hirotsu, Yosuke, Amemiya, Kenji, Oyama, Toshio, Mochizuki, Hitoshi, Omata, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849194/
https://www.ncbi.nlm.nih.gov/pubmed/31711486
http://dx.doi.org/10.1186/s12920-019-0610-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849194/
https://www.ncbi.nlm.nih.gov/pubmed/31711486
http://dx.doi.org/10.1186/s12920-019-0610-8

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