Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis

M. tuberculosis (Mtb) is a pathogenic bacterium that causes tuberculosis, which kills more than 1.5 million people worldwide every year. Strains resistant to available antibiotics pose a significant healthcare problem. The enormous complexity of the ribosome poses a barrier for drug discovery. We ha...

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Detalles Bibliográficos
Autores principales: Tam, Benjamin, Sherf, Dror, Cohen, Shira, Eisdorfer, Sarah Adi, Perez, Moshe, Soffer, Adam, Vilenchik, Dan, Akabayov, Sabine Ruth, Wagner, Gerhard, Akabayov, Barak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849635/
https://www.ncbi.nlm.nih.gov/pubmed/31803448
http://dx.doi.org/10.1039/c9sc02520k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849635/
https://www.ncbi.nlm.nih.gov/pubmed/31803448
http://dx.doi.org/10.1039/c9sc02520k

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