Intrinsic differences between FVIIIa mimetic bispecific antibodies and FVIII prevent assignment of FVIII‐equivalence

ESSENTIALS: Non‐factor VIII (FVIII) therapies for hemophilia A, such as bispecific antibodies (bsAbs), are in development. Bispecific antibodies are intrinsically different from FVIII and lack many of the same regulatory mechanisms. These differences complicate assignment and interpretation of FVIII...

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Detalles Bibliográficos
Autores principales: Leksa, Nina C., Aleman, Maria M., Goodman, Allison G., Rabinovich, Deana, Peters, Robert, Salas, Joe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
HAEMOSTASIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850022/
https://www.ncbi.nlm.nih.gov/pubmed/30887655
http://dx.doi.org/10.1111/jth.14430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850022/
https://www.ncbi.nlm.nih.gov/pubmed/30887655
http://dx.doi.org/10.1111/jth.14430

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