Mesenchymal Cell‐Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation

Human genetic evidence demonstrates that WNT1 mutations cause osteogenesis imperfecta (OI) and early‐onset osteoporosis, implicating WNT1 as a major regulator of bone metabolism. However, its main cellular source and mechanisms of action in bone remain elusive. We generated global and limb bud mesen...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Fan, Tarkkonen, Kati, Nieminen‐Pihala, Vappu, Nagano, Kenichi, Majidi, Rana Al, Puolakkainen, Tero, Rummukainen, Petri, Lehto, Jemina, Roivainen, Anne, Zhang, Fu‐Ping, Mäkitie, Outi, Baron, Roland, Kiviranta, Riku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850336/
https://www.ncbi.nlm.nih.gov/pubmed/30690791
http://dx.doi.org/10.1002/jbmr.3680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850336/
https://www.ncbi.nlm.nih.gov/pubmed/30690791
http://dx.doi.org/10.1002/jbmr.3680

Ejemplares similares