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The history of the two‐signal model of lymphocyte activation: A personal perspective

The first ideas leading to The Two‐Signal Model of lymphocyte activation were published 50 years ago, but the model was not realized in one sitting. I describe the three phases that led to its contemporary formulations. A motivation underlying all these models was to generate a minimal description o...

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Detalles Bibliográficos
Autor principal: Bretscher, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850391/
https://www.ncbi.nlm.nih.gov/pubmed/30825214
http://dx.doi.org/10.1111/sji.12762